The move clears a spot on the 40-man roster for right-hander Ethan Pecko, who was called up from Triple-A Sugar Land ahead of his scheduled start Wednesday against the Angels. Matthews has been on the shelf since July 17 due to a left knee sprain. He had been targeting a return to action for the Astros before the end of the month and had resumed hitting, fielding ground balls and running as of Aug. 8, per MLB.com. However, as a result of his move to the 60-day IL, Matthews won't be eligible for activation until Sept. 12.

Per MLB.com, Matthews has been cleared to field grounders and hit on the field, but he has yet to resume running at full speed since landing on the injured list July 17 due to a left knee sprain. Before going down with the injury, Matthews had made six starts in center field over a seven-game stretch, but he'll be in search of playing time elsewhere once he returns after Houston acquired Daulton Varsho from Toronto on Monday.